why has phenacetin been removed from aspirin ?

KusamaKollector

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Why has phenacetin been removed from aspirin?
It was introduced into the pharmaceutical market in 1887. However, it was withdrawn in 1983 in the United States due to unacceptable levels of interstitial nephritis in patients and potential risks of tumorigenicity. Like in the United States, most Western countries did not ban phenacetin from marketing until 1983.
 

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