what is the mechanism of action of acacetin ?

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Eliza

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What is the mechanism of action of acacetin?
Acacetin is a natural flavone that remarkably upregulates PINK1 and PRKN expression, and induces SIRT1 activation, leading to activation of the sirtuin 6 (SIRT6)‐AMPK signaling, which promotes PINK1‐PRKN mitophagy and thereby can prevent cellular senescence in a concentration-depending manner in rat H9C2 cardiomyocytes ...
 
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